Detection of active heteropolymeric beta-glucuronidase in hybrids between mouse cells and human fibroblasts with beta-glucuronidase deficiency.
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چکیده
منابع مشابه
Presentation of mucopolysaccharidosis VII (beta-glucuronidase deficiency) in infancy.
A child is presented with mucopolysaccharidosis VII (beta-glucuronidase deficiency), bringing to six the number of reported patients with the infantile onset form of this disorder. This patient exhibited the following features, previously unrecognised as part of this syndrome: presentation in the neonatal period, progressive joint contractures, and hydrocephalus. This child's course and data fr...
متن کاملStudies of Interspecific (Rat x Mouse) Somatic Hybrids. II. Lactate Dehydrogenase and beta-GLUCURONIDASE.
N the first paper of this series (WEISS and EPHRUSSI 1966), we described the I isolation of several different rat x mouse somatic hybrids and some of their properties. Study of their karyotypes showed that, although they lose some chromosomes in the course of successive generations, the hybrid cells retain major portions of both “parental” genomes over prolonged periods of time. The purpose of ...
متن کاملEsterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.
Excess dietary vitamin A is esterified with fatty acids and stored in the form of retinyl ester (RE) predominantly in the liver. According to the requirements of the body, liver RE stores are hydrolyzed and retinol is delivered to peripheral tissues. The controlled mobilization of retinol ensures a constant supply of the body with the vitamin. Currently, the enzymes catalyzing liver RE hydrolys...
متن کاملBeta Glucuronidase-rich Cytoplasmic Particles in Androgen-stimulated Mouse Kidney
Androgens produced by stimulating mouse testis with gonadotropic hormones cause a rise in renal beta-glucuronidase but not an increase in acid or alkaline phosphatase. All subcellular components increase in beta-glucuronidase activity, with a relatively greater increment in particulate enzyme as compared with that free in the cytoplasm (non-sedimentable). A small percentage of recovered beta-gl...
متن کاملFoamy changes of placental cells in probable beta glucuronidase deficiency associated with hydrops fetalis.
Mucopolysaccharidosis type VII (MPS VII, beta glucuronidase deficiency) has been described in association with non-immune hydrops fetalis. Three consecutive pregnancies in an itinerant family, which resulted in stillbirths caused by non-immune hydrops are described. The parents were closely related and there was a strong family history of storage disorders. The main clue to the diagnosis, howev...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1977
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.74.7.2948